Selective reduction of oxo bile acids: synthesis of 3 beta-, 7 beta-, and 12 beta-hydroxy bile acids.
نویسندگان
چکیده
منابع مشابه
Epimerization of the 7-hydroxy group of bile acids by the combination of two kinds of microorganisms with 7 alpha- and 7 beta-hydroxysteroid dehydrogenase activity, respectively.
An unidentified gram-positive anaeroic organism capable of dehydrogenating the 7 beta-hydroxy group of ursodeoxycholic acid was recovered from human feces. By combined action of this organism with the ordinary 7 alpha-dehydrogenating bacteria, chenodeoxycholic acid and cholic acid alike were readily converted into their respective 7 beta-epimers and the reverse reactions were also carried out. ...
متن کاملBile acids: regulation of synthesis.
Bile acids are physiological detergents that generate bile flow and facilitate intestinal absorption and transport of lipids, nutrients, and vitamins. Bile acids also are signaling molecules and inflammatory agents that rapidly activate nuclear receptors and cell signaling pathways that regulate lipid, glucose, and energy metabolism. The enterohepatic circulation of bile acids exerts important ...
متن کاملDocking studies and anti-inflammatory activity of beta-hydroxy-beta-arylpropanoic acids.
The article describes a two-step synthesis of diastereomeric 3-hydroxy-2-methyl-3-(4-biphenylyl)butanoic acids. In the first step an intermediate alpha-bromo propanoic acid 1-ethoxyethyl ester was synthesized. The second step is a new modified Reformatsky reaction in presence of Zn in tetrahydrofuran (THF) at -5 to 10 degrees C between the previously synthesized intermediate and 4-acetylbipheny...
متن کاملDevelopmental pattern of 3-oxo-Ä bile acids in neonatal bile acid metabolism
Aims—To investigate whether a fetal pathway of bile acid synthesis persists in neonates and infants. Methods—3-oxo-Ä bile acids were determined qualitatively and quantitatively in the urine, meconium, and faeces of healthy neonates and infants, using gas chromatography–mass spectrometry. Results—The mean percentage of 3-oxo-Ä bile acids in total bile acids in urine at birth was significantly hi...
متن کاملOST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids.
The organic solute and steroid transporter, Ost alpha-Ost beta, is an unusual heteromeric carrier that appears to play a central role in the transport of bile acids, conjugated steroids, and structurally-related molecules across the basolateral membrane of many epithelial cells. The transporter's substrate specificity, transport mechanism, tissue distribution, subcellular localization, transcri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1991
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)41994-7